Bioss Inc.'s NXF1 (1G8) Monoclonal Antibody is a Rabbit monoclonal antibody. The NXF1 (1G8) Monoclonal Antibody was generated using Nxf1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Precipitation, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export